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  • 1 Faculty of Pharmaceutical Science of the USP/SP Department of Pharmacy Av. Professor Lineu Prestes, 580 Săo Paulo/ SP CEP 05508-910 C.P. 66083 Brazil Av. Professor Lineu Prestes, 580 Săo Paulo/ SP CEP 05508-910 C.P. 66083 Brazil
  • 2 Institute of Chemistry of the USP/SP Department of Fundamental Chemistry Brazil Brazil
  • 3 Oxiteno S/A - Commercial and Industry Brazil Brazil
  • 4 Butantan Institute Brazil Brazil
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Abstract  

Oxamniquine (OXA) is a schistosomicide agent that causes some adverse effects in central nervous system. Intending to improve OXA therapeutic properties, a polymeric prodrug was designed. Currently, there is an increasing interest of thermal analytical techniques in the pharmaceutical area, so differential thermal analysis (DTA) and thermogravimetry (TG) were carried out to evaluate the thermal behavior of OXA, polymethacrylic acid (PMA), [poly(methacrylic-co-oxamniquine methacrylate)acid] (PMOXA) and physical mixture (OXA+PMA). The thermoanalytical profile of the physical mixture showed characteristic events of the thermal decomposition of OXA and PMA. Distinctly, PMOXA DTA curve did not show an endothermic peak at 148.5C indicating that the drug was incorporated into the polymeric system. These results were corroborated by the IR spectroscopy and X-ray diffraction data.

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