γ-Cyclodextrin and dimethyl-β-cyclodextrin were used as solubilizing agents for a very poorly water-soluble drug, an imidazole
derivative antifungal agent, clotrimazole; with the aim of improving the physicochemical properties of the drug. Solid products
were prepared by physical mixing, kneading, precipitation and spray-drying methods in 1:1 and 1:2 drug:cyclodextrin molar
ratios. Drug interactions were studied by thermoanalytical methods such as DSC, DTA, TG and DTG, X-ray diffractometry and
Fourier transformation-infrared spectroscopy. The results demonstrated the formation of inclusion complexes in some products.