View More View Less
  • 1 University of Ege Department of Pharmaceutical Technology, Faculty of Pharmacy 35100 Izmir Turkey 35100 Izmir Turkey
  • | 2 University of Szeged Department of Pharmaceutical Technology 6720 Szeged Eötvös u. 6 Hungary 6720 Szeged Eötvös u. 6 Hungary
  • | 3 University of Szeged Department of Physical Chemistry 6720 Szeged Rerrich Béla tér 1 Hungary 6720 Szeged Rerrich Béla tér 1 Hungary
Restricted access

Abstract  

γ-Cyclodextrin and dimethyl-β-cyclodextrin were used as solubilizing agents for a very poorly water-soluble drug, an imidazole derivative antifungal agent, clotrimazole; with the aim of improving the physicochemical properties of the drug. Solid products were prepared by physical mixing, kneading, precipitation and spray-drying methods in 1:1 and 1:2 drug:cyclodextrin molar ratios. Drug interactions were studied by thermoanalytical methods such as DSC, DTA, TG and DTG, X-ray diffractometry and Fourier transformation-infrared spectroscopy. The results demonstrated the formation of inclusion complexes in some products.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2021 0 0 0
Feb 2021 0 0 0
Mar 2021 0 0 0
Apr 2021 0 0 0
May 2021 0 0 0
Jun 2021 0 0 0
Jul 2021 0 0 0