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  • 1 University of Ljubljana Faculty of Pharmacy Aškerčeva 7 1000 Ljubljana Slovenia Aškerčeva 7 1000 Ljubljana Slovenia
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Abstract  

The phase diagrams of nifedipine-polyethylene glycol (PEG) 4000 and nifedipine-mannitol systems have been determined. Heating experiments on thermodynamically equilibrated co-melts revealed eutectic behaviour for nifedipine-PEG 4000 mixtures, with the composition of the eutectic point between 40 and 45%w/w of nifedipine. These observations were supported by optical and hot stage microscopy. Nifedipine and mannitol were negligibly miscible in the solid-state, behaving as a binary system with monotectic characteristics. Application of phase diagrams to the production of solid dispersions is shown to be rational, since they provide valuable information on the state of the binary systems under preparation.

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  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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