Universidade Federal do Rio Grande do Norte, Centro de Cięncias de Saúde Departamento de Farmácia Av. Gal. Cordeiro de Farias s/n - Petrópolis 59010-180 Natal, RN Brazil Av. Gal. Cordeiro de Farias s/n - Petrópolis 59010-180 Natal, RN Brazil
Budapest University of Technology and Economics Institute of General and Analytical Chemistry Szt. Gellért tér 4 H-1111 Budapest Hungary Szt. Gellért tér 4 H-1111 Budapest Hungary
Budapest University of Technology and Economics, Research Group of Technical Analytical Chemistry Hungarian Academy of Sciences Szt. Gellért tér 4 H-1111 Budapest Hungary Szt. Gellért tér 4 H-1111 Budapest Hungary
Thermoanalytical techniques, being rapid and un-expensive have been used for the investigation of the cyclodextrin inclusion
complexes for three decades. The conventional thermoanalytical techniques (TG and DTA/DSC) follow the thermal properties of
the uncomplexed compounds. Consequently, the inclusion complex formation as well as the liberation of the entrapped guest
cannot be followed. Monitoring the products of the thermal fragmentation of parent cyclodextrin and the included molecule(s),
applying TG-MS combined technique provides evidence concerning the inclusion complex formation, and besides, gives selective
signal to follow the decomposition of the cyclodextrin inclusion complexes. b-cyclodextrin inclusion complexes of Thymol and
Lippia sidoides Cham essential oil extract have been prepared and investigated using conventional and combined (TG-MS) thermoanalytical techniques.
The evolved gas analysis proved the inclusion complex formation between the host and guests. By the evaluation of the experimental
results the elaboration of the entrapped guests from the cyclodextrin cavity could be followed.