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  • 1 Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, Eötvös u. 6, Hungary
  • | 2 Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, Eötvös u. 6, Hungary
  • | 3 Department of Physical Chemistry, University of Szeged 6720 Szeged, Rerrich Béla tér 1, Hungary
  • | 4 Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, Eötvös u. 6, Hungary
  • | 5 Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, Eötvös u. 6, Hungary
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Summary Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.

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