Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 81: Issue 2
Characterization and quantification of amorphous content in some selected parenteral cephalosporins by calorimetric method
Authors:
R. Chadha Pharmaceutical Chemistry Division, University Institute of Pharmaceutical Sciences, Panjab University Chandigarh 160014, India

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N. Kashid Pharmaceutical Chemistry Division, University Institute of Pharmaceutical Sciences, Panjab University Chandigarh 160014, India

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D. V. S. Jain Department of Chemistry, Panjab University Chandigarh 160014, India

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Pages:
277–284
Online Publication Date:
12 Aug 2005
Publication Date:
01 Jul 2005
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-005-0779-2
Keywords:
enthalpy of solution; solution calorimetry; cephalosporins; crystallinity determination
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Summary Amorphous content of a crystalline drug affects its physical and chemical properties as well as its performance. Consequently it is important to assess the extent of amorphous contents in pharmaceuticals. The present study utilizes the technique of solution calorimetry to quantify the percentage of crystallinity in samples of varying amorphous content in cefazolin sodium monohydrate, ceftriaxone sodium, cefotaxime sodium and cefoperazone sodium. Enthalpy of solution of 100% crystalline and amorphous drugs as well as their physical mixtures over the range 0-100 mass/mass% amorphous content were determined. As expected it has been found that amorphous forms have significantly higher energy than the corresponding crystalline form for all the drugs. Enthalpy of solution (ΔsolH), an extensive thermodynamic property can provide a precise and unambiguous measure of the relative crystallinity provided amorphous and crystalline standards are appropriately chosen. A good correlation has been found between ΔsolH and the amorphous contents of the drugs.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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