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  • 1 University of Pécs, Faculty of Medicine, Department of Byophysics Pécs, Szigeti str. 12, 7624, Hungary Pécs, Szigeti str. 12, 7624, Hungary
  • | 2 University of Pécs, Faculty of Medicine, Department of Biophysics Pécs, Szigeti str. 12, H-7624, Hungary Pécs, Szigeti str. 12, H-7624, Hungary
  • | 3 Research Group for Fluoresence Spectroscopy, Office for Academy Research Groups Attached to Universities Pécs, Szigeti str. 12, 7624, Hungary Pécs, Szigeti str. 12, 7624, Hungary
  • | 4 University of Pécs, Faculty of Medicine, Department of Byophysics Pécs, Szigeti str. 12, 7624, Hungary Pécs, Szigeti str. 12, 7624, Hungary
  • | 5 University of Pécs, Faculty of Medicine, Department of Byophysics, Pécs, Szigeti str. 12, 7624, Hungary Pécs, Szigeti str. 12, 7624, Hungary
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Summary  

The effect of pH was characterised on the thermal stability of magnesium saturated skeletal and cardiac α-actin isoforms with differential scanning calorimetry (DSC) at pH 7.0 and 8.0. The calorimetric curves were further analysed to calculate the enthalpy and transition entropy changes. The activation energy was also determined to describe the energy consumption of the initiation of the thermal denaturation process. Although the difference in Tmvalues is too small to interpret the difference between the a-actin isoforms, the values of the activation energy indicated that the α-skeletal actin is probably more stable compared to the α-cardiac actin. The difference in the activation energies indicated that lowering the pH can produce a more stable protein matrix in both cases of the isoforms. The larger range of the difference in the values of the activation energies suggested that the α-cardiac actin is probably more sensitive to the change of the pH compared to the α -skeletal actin.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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