View More View Less
  • 1 Monash University Victorian College of Pharmacy Parkville, Victoria Australia 3052 381 Royal Parade Parkville, Victoria Australia 3052 381 Royal Parade
  • | 2 University of London, School of Pharmacy London UK WC1N 1AX 29-39 Brunswick Square London UK WC1N 1AX 29-39 Brunswick Square
  • | 3 Thermal Hazard Technology, 1 North House Bletchley, Buckinghamshire UK MK1 1SW Bond Avenue Bletchley, Buckinghamshire UK MK1 1SW Bond Avenue
Restricted access

Abstract  

Isothermal calorimetry is becoming indispensable as a tool for the study of a wide variety of systems. As with all scientific instruments it is essential that robust calibration routines be developed in order to validate the data obtained. Chemical test reactions offer many advantages over (the traditionally used) joule effect heating methods, not least because they have the potential to validate instrument performance (i.e. they can be used to assess all aspects of calorimeter operation). In this work the results of a validation exercise, conducted by Thermal Hazard Technology as part of an installation routine, using the base catalysed hydrolysis of methyl paraben are discussed. In the case described, a systematic misreporting of the reported temperature of a calorimeter was identified, caused by an upgrade to the calorimeter's firmware, a discrepancy which may not have been noted using traditional electrical calibration methods and one which highlights the importance of both manufacturers and end-users adopting chemical test reactions into their test and validation routines.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2021 3 0 0
Feb 2021 0 0 0
Mar 2021 0 0 0
Apr 2021 0 0 0
May 2021 1 0 0
Jun 2021 0 0 0
Jul 2021 0 0 0