Massive bleeding from oesophagus varices presents
a life threatening complication of liver cirrhosis. No effective method of
treatment is available until now, that would guarantee high grade of patient
wellness during the conditioning and investigation phase until the definitive
treatment could be introduced.
The fact that we have not found any report in the
literature about self-expandable metal stents (SEMS) application in acute
variceal bleeding had encouraged us to use stents usually used for oesophageal
malignancy and furthermore develop a special stent for this individual indication.
The aim of this study
was to evaluate the tissue response to oesophagus stent designed for stop
acute variceal bleeding in animal experiment in compare with another stent
used for iatrogenic treatment of different strictures of the oesophagus. Tissue
oxygen saturation (StO2) measurement was performed
before and after the implantation of the stents. Macroscopic and histological
investigations of the stented oesophagus segments were observed after 10 days.
calorimeter (DSC) is a well-established method for the demonstration of thermal
consequences of local and global conformational changes in biological systems,
but it has never been used for the investigation of the oesophagus. According
to our results the thermal denaturation of intact oesophagus, its mucosa and
muscle fragments revealed significant differences compared to healthy sample
in favour of the new stent.