Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 84: Issue 1
Differential scanning microcalorimetry study of thermal stability of nevirapine and azidothymidine mixture
Authors:
K. Michalik A. Chełkowski’ Institute of Physics, Department of Medical Physics University of Silesia Katowice Poland 40–007 Ul. Uniwersytecka 4 Katowice Poland 40–007 Ul. Uniwersytecka 4

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Zofia Drzazga A. Chełkowski’ Institute of Physics, Department of Medical Physics University of Silesia Katowice Poland 40–007 Ul. Uniwersytecka 4 Katowice Poland 40–007 Ul. Uniwersytecka 4

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Anna Michnik A. Chełkowski’ Institute of Physics, Department of Medical Physics University of Silesia Katowice Poland 40–007 Ul. Uniwersytecka 4 Katowice Poland 40–007 Ul. Uniwersytecka 4

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M. Kaszuba Department of Conservative and Peropdontology Medical University of Silesia Bytom Poland 41-902 Pl. Akademicki 17 Bytom Poland 41-902 Pl. Akademicki 17

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Pages:
119–123
Online Publication Date:
14 Apr 2006
Publication Date:
14 Apr 2006
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-005-7171-0
Keywords:
azidothymidine; nevirapine; thermal analysis interaction
Restricted access

Abstract  

A differential scanning calorimetry study of the thermal behavior of nevirapine and azidothymidine in water solution was carried out. For nevirapine scan rate dependent and irreversible endothermic peak were found. Thermal degradation of nevirapine as well as NVP – AZT mixture is relatively well described by the model involving only one irreversible step determined by a first-order rate constant. The estimated kinetic constants and activation energies indicate that the degradation process proceeds slower for nevirapine in presence of AZT ligands than without them.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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