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  • 1 A. Chełkowski’ Institute of Physics, Department of Medical Physics University of Silesia Katowice Poland 40–007 Ul. Uniwersytecka 4 Katowice Poland 40–007 Ul. Uniwersytecka 4
  • | 2 Department of Conservative and Peropdontology Medical University of Silesia Bytom Poland 41-902 Pl. Akademicki 17 Bytom Poland 41-902 Pl. Akademicki 17
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Abstract  

A differential scanning calorimetry study of the thermal behavior of nevirapine and azidothymidine in water solution was carried out. For nevirapine scan rate dependent and irreversible endothermic peak were found. Thermal degradation of nevirapine as well as NVP – AZT mixture is relatively well described by the model involving only one irreversible step determined by a first-order rate constant. The estimated kinetic constants and activation energies indicate that the degradation process proceeds slower for nevirapine in presence of AZT ligands than without them.

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