scanning calorimetry study of the thermal behavior of nevirapine and azidothymidine
in water solution was carried out. For nevirapine scan rate dependent and
irreversible endothermic peak were found. Thermal degradation of nevirapine
as well as NVP – AZT mixture is relatively well described by the model
involving only one irreversible step determined by a first-order rate constant.
The estimated kinetic constants and activation energies indicate that the
degradation process proceeds slower for nevirapine in presence of AZT ligands
than without them.