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  • 1 Semmelweis University University Pharmacy, Department of Pharmacy Administration Budapest Hungary 1092 Hőgyes E. u. 7–9
  • 2 Hungarian Academy of Sciences, Budapest University of Technology and Economics Research Group of Technical Analytical Chemistry Budapest Hungary 1111 Szt. Gellért tér 4
  • 3 University of Technology and Economics Institute of General and Analytical Chemistry Budapest Hungary 1111 Szt. Gellért tér 4
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Abstract  

The purpose of the present work was to study the compatibility of metronidazole with different pharmaceutical excipients (hydroxypropyl methylcellulose, poly(ethylene oxide), microcrystalline cellulose, dicalcium phosphate dihydrate, and anhydrous dicalcium phosphate) using differential scanning calorimetry and diffuse reflectance spectroscopy. Dicalcium phosphate dihydrate was the only excipient that showed interaction with metronidazole even before storage. Changes referring to a possible transition to dihydrate form were observed in the thermal curves of anhydrous dicalcium phosphate after four weeks of storage. Although dicalcium phosphate dihydrate can be replaced by the anhydrous form in pharmaceutical formulations, the observed transition might negatively influence the stability of dosage forms.

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