Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 85: Issue 1
Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate
Authors: B. Howell 1 , D. Fan 1 , and Leela Rakesh 1
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  • 1 Central Michigan University Center for Applications in Polymer Science Mt. Pleasant USA 48859-0001 MI Mt. Pleasant USA 48859-0001 MI
Pages:
17–20
Online Publication Date:
26 Jul 2006
Publication Date:
01 Jul 2006
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-005-7333-0
Keywords:
dendrimer-based organoplatinum drugs; drug delivery; polymeric drugs; thermal decomposition; time-release drugs
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Abstract  

A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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