Authors:
H. Aki Fukuoka University Faculty of Pharmaceutical Sciences Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku

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Y. Nakashima Fukuoka University Faculty of Pharmaceutical Sciences Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku

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Y. Kawasaki Fukuoka University Faculty of Pharmaceutical Sciences Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku

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T. Niiya Fukuoka University Faculty of Pharmaceutical Sciences Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku Fukuoka Japan 814-0180 8-19-1 Nanakuma, Jonan-ku

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Abstract  

The antibacterial action of amoxicillin (AMPC) and the inclusion complexes of AMPC with α-, β- and γ-cyclodextrins (α-CD, β-CD and γ-CD, respectively) to Escherichia coli B (E. coli) was evaluated by isothermal titration microcalorimetry and by petri-dish bioassay method. The effects of the compounds on produced heat during the exponential phase of the E. coli growing were measured and the growing rate constants of the cells was calculated from the power-time (p-t) curve before and after the treatment with AMPC. Results from the both methods showed that the antibacterial activity became stronger in the following order: AMPC-βCD > AMPC-γCD ≈ AMPC-αCD > AMPC only.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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