Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 86: Issue 2
Thermoanalytical study of microspheres containing diltiazem hydrochloride
Authors:
T. Hekmatara University of Szeged Department of Pharmaceutical Technology Szeged Hungary 6720 Eötvös St. 6. Szeged Hungary 6720 Eötvös St. 6.

Search for other papers by T. Hekmatara in
Current site
Google Scholar
PubMed Close
,
G. Regdon University of Szeged Department of Pharmaceutical Technology Szeged Hungary 6720 Eötvös St. 6. Szeged Hungary 6720 Eötvös St. 6.

Search for other papers by G. Regdon in
Current site
Google Scholar
PubMed Close
,
P. Sipos University of Szeged Department of Pharmaceutical Technology Szeged Hungary 6720 Eötvös St. 6. Szeged Hungary 6720 Eötvös St. 6.

Search for other papers by P. Sipos in
Current site
Google Scholar
PubMed Close
,
I. Erős University of Szeged Department of Pharmaceutical Technology Szeged Hungary 6720 Eötvös St. 6. Szeged Hungary 6720 Eötvös St. 6.

Search for other papers by I. Erős in
Current site
Google Scholar
PubMed Close
, and
K. Pintye-Hódi University of Szeged Department of Pharmaceutical Technology Szeged Hungary 6720 Eötvös St. 6. Szeged Hungary 6720 Eötvös St. 6.

Search for other papers by K. Pintye-Hódi in
Current site
Google Scholar
PubMed Close
Pages:
287–290
Online Publication Date:
27 Jun 2006
Publication Date:
01 Nov 2006
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-005-7303-6
Keywords:
chitosan; diltiazem hydrochloride; DSC; microspheres; TG
Restricted access

Abstract  

The main purpose of our study was to produce microspheres containing diltiazem hydrochloride and to perform the thermoanalytical examination of the components and microspheres. Thermal analysis is a very frequently used method in the preformulation tests of solid dosage forms. Diltiazem hydrochloride is a calcium-channel blocker with short biological half life, so it is a potential candidate for sustained or controlled release dosage forms. Various techniques are available for the microencapsulation of drugs. The technique of spray-drying was used during our investigations. It was found that the crystalline form of the active agents could not be observed in the drug-loaded chitosan microspheres, which indicates the molecular dispersion of the drug in the matrix. It was established that the preparation conditions influenced the morphology and size of the particles. Moreover, the sphericity of the microspheres was good. On the basis of our investigations, the 1:1 diltiazem hydrochloride–chitosan ratio is suggested as the best ratio.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2024 5 0 0
May 2024 1 0 0
Jun 2024 13 0 0
Jul 2024 5 0 0
Aug 2024 7 0 0
Sep 2024 15 0 0
Oct 2024 7 0 0