Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 87: Issue 3
Thermal and kinetic study of statins
Simvastatin and lovastatin
Authors:
M. Souza Universidade Federal da Paraíba, CCEN Departamento de Química João Pessoa Brazil CEP 58059-900 PB Campus I

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Marta Conceição Universidade Federal de Campina Grande Centro de Educação e Saúde Cuité Brazil PB Campus Cuité

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M. Silva Universidade Federal da Paraíba, CCEN Departamento de Química João Pessoa Brazil CEP 58059-900 PB Campus I

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L. Soledade Universidade Federal da Paraíba, CCEN Departamento de Química João Pessoa Brazil CEP 58059-900 PB Campus I

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A. Souza Universidade Federal da Paraíba, CCEN Departamento de Química João Pessoa Brazil CEP 58059-900 PB Campus I

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Pages:
859–863
Online Publication Date:
09 Mar 2007
Publication Date:
01 Mar 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-006-8193-y
Keywords:
kinetic; statins; thermogravimetry
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Abstract  

Statins are a group of lipoproteins that are used in medicine to treat the high cholesterol level. The effectiveness of statins in reducing the cholesterol level is significant and in long time scale the reduction of the cholesterol level helps to avoid the incidence of degenerative diseases. Simvastatin and lovastatin are belonging to the ‘statins’ family, one of the pharmacologic groups used in the control of dislipidemy. The objective of this work is the thermal stability and kinetic study of the active forms of simvastatin and lovastatin. Thermal data indicated that lovastatin and simvastatin are stable up to 190 and 170°C in air and up to 205 and 203°C in nitrogen, respectively. For melting temperatures DSC curves showed good correlation with the literature data. Comparing the activation energies of the statins at heating rate of 10°C min–1, lovastatin is more stable than simvastatin under the applied experimental conditions.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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