Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 87: Issue 3
Development of thermogravimetric method to quantitative determination of mebendazole
Authors:
Ana Gomes Cidade Universitária Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM João Pessoa Brazil 58051-970 Paraíba Campus I CCS João Pessoa Brazil 58051-970 Paraíba Campus I CCS

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Lidiane Correia Cidade Universitária Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM João Pessoa Brazil 58051-970 Paraíba Campus I CCS João Pessoa Brazil 58051-970 Paraíba Campus I CCS

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Mônica da Silva Simões Cidade Universitária Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM João Pessoa Brazil 58051-970 Paraíba Campus I CCS João Pessoa Brazil 58051-970 Paraíba Campus I CCS

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Rui Macêdo Cidade Universitária Federal University of Paraíba UFPB, Unified Development and Medicine Assays Laboratories LUDEM João Pessoa Brazil 58051-970 Paraíba Campus I CCS João Pessoa Brazil 58051-970 Paraíba Campus I CCS

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Pages:
919–925
Online Publication Date:
09 Mar 2007
Publication Date:
01 Mar 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-006-7741-9
Keywords:
equation of Antoine; equation of Langmuir; mebendazole; thermogravimetry; vapor pressure
Restricted access

Abstract  

The objective of this work was to develop and validate a fast and reproducible method able to determine the concentration of mebendazole in raw materials and tablets. The samples were analyzed by dynamic thermogravimetry, in the heating rates of 10, 20, 40, 60 and 80C min–1, in the atmospheres of nitrogen and nitrogen with synthetic air. Obtained data were used in the equations of Antoine and Langmuir, with the purpose to get the pressure curves of those. Vapor pressure curves of drug and tablet of mebendazole were evaluated using the mathematical indexes of difference factor, f1, and similarity factor, f2, to compare its profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of mebendazole in both environmental conditions studied, what confirms that the process is really vaporization. The concentration of mebendazole was determined in the raw material and tablets with the drug.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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