Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 88: Issue 2
Technological quality determination of pharmaceutical disintegrant by DSC cooling and DSC photovisual
Authors:
Ana Medeiros

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Lidiane Correia Federal University of Paraíba Unified Laboratory of Medicine Development and Assay (LUDEM), Pharmacy Department João Pessoa Brazil 58059-900 Campus I Paraíba João Pessoa Brazil 58059-900 Campus I Paraíba

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Mônica Simões Stadual University of Paraíba Pharmacy Department Campina Grande Brazil Paraíba Campina Grande Brazil Paraíba

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R. Macêdo Federal University of Paraíba Unified Laboratory of Medicine Development and Assay (LUDEM), Pharmacy Department João Pessoa Brazil 58059-900 Campus I Paraíba João Pessoa Brazil 58059-900 Campus I Paraíba

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Pages:
311–315
Online Publication Date:
16 May 2007
Publication Date:
01 May 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-006-8005-4
Keywords:
crystallization water; disintegrants; DSC cooling; DSC photovisual and particles size
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Abstract  

A number of disintegrants are available on the market. They improve tablets’ disintegration. The objective of this work is the comparison of the technological quality parameters of disintegrants using different analytical techniques. Three batches of disintegrants and their binary mixtures (water:disintegrants) were investigated. Cooling experiments were used from –30 up to 200C. The data obtained showed calorimetric differences between the samples. In the binary mixtures water showed different crystallization behaviour from the one found in the literature. According to the results DSC technique helped the quality control of different disintegrants.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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