Federal University of Pernambuco – UFPE Pharmaceutical Sciences Department Recife Brazil 740-521 PE Artur de Sá Avenue, Cidade Universitária Recife Brazil 740-521 PE Artur de Sá Avenue, Cidade Universitária
Federal University of Paraíba – UFPB Unified Laboratories of Medicine Development and Assay – LUDEM João Pessoa Brazil 58059-900 PB Campus I João Pessoa Brazil 58059-900 PB Campus I
Stability of drugs
and products has a great practical interest, which is facing to strict regulation.
Thermal studies, besides the determination of the thermal properties of the
investigated product allow the verification of possible interactions between
the drug substances and excipients. The objective of this work was to obtain
solid pre-formulates of paracetamol (PC) by spray drying (SPDR), as well as
to investigate their thermal behavior. Dynamic and isotherm TG, conventional
DSC and DSC-photovisual coupled methods were used to characterize the conventional
and pre-formulated mixtures obtained by SPDR. The results of both DSC investigations
showed slight alterations in melting temperatures, which suggests incompatibilities.
The TG decomposition data of the mixtures evidenced that the dry process via
SPDR leads to stability enhancement of the pre-formulated mixtures.