Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 88: Issue 2
Development of thermogravimetric method for quantitative determination of metronidazole
Authors:
Ana Gomes Federal University of Paraíba – UFPB Unified Development and Medicine Assays Laboratories – LUDEM João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba

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Lidiane Correia Federal University of Paraíba – UFPB Unified Development and Medicine Assays Laboratories – LUDEM João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba

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Mônica da Silva Simões Federal University of Paraíba – UFPB Unified Development and Medicine Assays Laboratories – LUDEM João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba

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R. Macêdo Federal University of Paraíba – UFPB Unified Development and Medicine Assays Laboratories – LUDEM João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba João Pessoa Brasil 58051-970 Cidade Universitária, Campus I – CCS Paraíba

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Pages:
383–387
Online Publication Date:
16 May 2007
Publication Date:
01 May 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-006-8007-2
Keywords:
Antoine equation; Langmuir equation; metronidazole; thermogravimetry; vapor pressure
Restricted access

Abstract  

The objective of this work was to develop and validate a fast and reproducible method to determine the concentration of metronidazole in drug substance and tablets. The samples were analyzed by dynamic thermogravimetry, using 10, 20, 40, 60 and 80C min–1 heating rates in nitrogen and in nitrogen with synthetic air. Obtained data were used in the Antoine and Langmuir equations in order to have the pressure curves. Vapor pressure curves of drug and tablet of metronidazole were evaluated using the mathematical indexes of difference factor, f1, and similarity factor, f2, to compare their profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of metronidazole in both environmental conditions, which confirms that the process is really vaporization. The concentration of metronidazole was determined in the raw material and tablets of the drug.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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