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  • 1 University of Silesia A. Chełkowski’ Institute of Physics, Department of Medical Physics Katowice Poland 40–007 ul. Uniwersytecka 4
  • | 2 Medical University of Silesia Department of Conservative and Peropdontology Bytom Poland 41–902 Pl. Akademicki 17
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Abstract  

A thermal and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir sulfate, were carried out to find their thermal stability. DSC curves of both drugs showed exothermic transition. This observed process resulted in two steps. Obtained apparent activation energy pointed at low stability of studied protease inhibitors in water solutions.

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