Isothermal titration calorimetry (ITC) has been used to develop a method to construct the solid-liquid equilibrium line in
ternary systems containing the solute to precipitate and an aqueous mixed solvent. The method consists in measuring the heat
of dissolution of a solid component (the solute) during successive additions of the liquid solvent. The cumulated heat, resulting
from the successive heat peaks obtained for the different injections of known volumes of solvent, plotted vs. the ratio of the numbers of moles nsolvent/nsolute is represented by two nearly straight lines. The intercept of the two lines gives the solubility limit and the corresponding
enthalpy of dissolution of the solute in the solvent.
Solubility diagrams have been established at 303.15 K in binary mixed solvents ethanol-water over the whole concentration
range for seven compounds of pharmaceutical interest, namely: urea, phenylurea, l-valine, dl-valine, l-valine ethyl ester hydrochloride, tris(hydroxymethyl)amino methane.