Authors:
Antonilêni Medeiros Federal University of Pernambuco — UFPE Pharmaceutical Sciences Department Prof. Artur de Sá, s/n — University City Zip. 50 740-521 Recife PE Brazil

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Ana Santos Federal University of Pernambuco — UFPE Pharmaceutical Sciences Department Prof. Artur de Sá, s/n — University City Zip. 50 740-521 Recife PE Brazil

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F. de Souza LUDEM — Federal University of Paraíba — UFPB Unified Laboratory of Medicine Development and Assay Campus I Zip. 58059-900 João Pessoa PB Brazil

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I. Júnior LUDEM — Federal University of Paraíba — UFPB Unified Laboratory of Medicine Development and Assay Campus I Zip. 58059-900 João Pessoa PB Brazil

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J. Valdilânio
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J. Procópio LUDEM — Federal University of Paraíba — UFPB Unified Laboratory of Medicine Development and Assay Campus I Zip. 58059-900 João Pessoa PB Brazil

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D. de Santana Federal University of Pernambuco — UFPE Pharmaceutical Sciences Department Prof. Artur de Sá, s/n — University City Zip. 50 740-521 Recife PE Brazil

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R. Macêdo LUDEM — Federal University of Paraíba — UFPB Unified Laboratory of Medicine Development and Assay Campus I Zip. 58059-900 João Pessoa PB Brazil

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Abstract  

Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. The objective of the present work was to develop pre-formulated mixtures of metronidazole (MT) obtained by spray drying (SPDR) and their thermoanalytical characterization. Dynamic and isothermal TG, conventional DSC and DSC coupled to a photovisual system were used. DSC experiments with both techniques confirmed the homogeneity of the conventional and pre-formulated mixtures. The TG data made possible the comparison the thermal stability of the different mixtures. Similar thermal stabilities were found of the conventional and pre-formulated mixtures, with slower particles sizes of MT.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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