Thermal analysis of fusion and decomposition processes were carried out on recently synthetized pharmaceutical compounds in
order to establish thermal stability criteria. This study was carried out using thermogravimetry, TG, and differential scanning
calorimetry, DSC. Degradation and fusion temperatures have been produced as thermal data with the aim of to study the thermal
stability of the compounds.
Relationship is found among stability and a series of effects of structure of the compounds. The compounds which present an
amide functional group in the central molecule are more stable because they have a comparatively higher fusion and degradation
temperature. In addition, the stability of this type of compounds depends on the position of the electrophilic substitution
(in ortho, meta or para). Likewise, the groups linked to the aromatic ring with high electronic density give stability, and therefore are able to
delocalize the charge in a greater spacial interval.
Therefore, criteria for the selection of substituents have established that improve the stability of compounds