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  • 1 University of Szeged Faculty of Medicine Department of Orthopaedics Semmelweis u. 6 6725 Szeged Hungary
  • | 2 University of Szeged, Faculty of Pharmacy Department of Pharmaceutical Technology Eötvös u. 6 6720 Szeged Hungary
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Abstract  

Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in the extracellular matrix in osteoarthritis comes from animal models. Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which proved water content elevation contributing to disease progression.

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