Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 89: Issue 3
Microcalorimetric investigation of the growth of the Escherichia coli DH5α in different antibiotics
Authors:
L. Yang

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S. Qiu

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F. Xu Chinese Academy of Sciences Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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L. Sun Chinese Academy of Sciences Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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Z. Zhao Chinese Academy of Sciences Division of Biotechnology, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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J. Liang Hunan Institute of Drug Detection Changsha 410001 P.R. China

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C. Song Dalian Institute of Drug Detection Dalian 116021 P.R. China

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Pages:
875–879
Online Publication Date:
13 Feb 2007
Publication Date:
01 Sep 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-006-7902-x
Keywords:
Amoxicillin Sodium; Cefuroxime Sodium; E. coli DH5α; inhibition; microcalorimetry
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Abstract  

The effects of Amoxicillin Sodium and Cefuroxime Sodium on the growth of E. coli DH5α were investigated by microcalorimetry. The metabolic power-time curves of E. coli DH5α growth were determined by using a TAM air isothermal microcalorimeter at 37�C. By evaluation of the obtained parameters, such as growth rate constants (k), inhibitory ratio (I), the maximum heat power (Pm) and the time of the maximum heat power (tm), one found that the inhibitory activity of Amoxicillin Sodium vs. E. coli DH5α is enhanced with the increasing of the Amoxicillin Sodium concentration, and the Cefuroxime Sodium has a stimulatory effect on the E. coli DH5α growth when the concentration is about 1 μg mL−1. The IC50 for the Amoxicillin Sodium and the Cefuroxime Sodium are 1.6 and 2.0 μg mL−1, respectively, it implicates that the E. coli DH5α is more sensitive to Amoxicillin Sodium than Cefuroxime Sodium.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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