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  • 1 Chinese Academy of Science State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics Dalian 116023 China
  • | 2 Qufu Normal University Department of Chemistry Qufu Shandong 273165 China
  • | 3 Chinese Academy of Science Thermochemistry Laboratory, Dalian Institute of Chemical Physics Dalian 116023 China
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Abstract  

The isoquinoline alkaloids were isolated from traditional Chinese drugs of Phellodendri Cortex, Radix Stephaniae Tetrandrae, Corydalis Yanhusuo and Corydalis Bungeana. The power-time curves of growth of E. coli at different concentrations of isoquinoline alkaloid at 37�C were determined by a 2277 Thermal Activity Monitor. The rate constant of bacteriostastic activity was calculated. The relationship between growth rate constant and concentration was established. The optimum bacteriostastic concentration was determined. Experimental results have indicated that all the isoquinoline alkaloids isolated from the four kinds of traditional Chinese drugs have bacteriostastic activity and the order is Phellodendri Cortex>Radix Stephaniae Tetrandrae>Corydalis Yanhusuo>Corydalis Bungeana.