Authors:
Beatrice Nicolaï Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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P. Espeau Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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R. Céolin Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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M. Perrin Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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L. Zaske Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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J. Giovannini AstraZeneca R and D 221 87 Lund Sweden

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F. Leveiller AstraZeneca R and D 221 87 Lund Sweden

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Abstract  

Spironolactone (C24H32O4S) usually crystallizes into an orthorhombic phase, named Form II. Another orthorhombic phase, named Form I, is also known but seems difficult to obtain. Studies of the kinetics of desolvation of the ethanol solvate at room temperature showed that these two forms can be obtained through different mechanisms of desolvation.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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