Authors:
P. Espeau Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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B. Nicolaï Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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R. Céolin Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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M. Perrin Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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L. Zaske Faculté de Pharmacie Laboratoire de Chimie Physique, EA 4066 4 av. de l’Observatoire 75006 Paris France

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J. Giovannini AstraZeneca R and D 221 87 Lund Sweden

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F. Leveiller AstraZeneca R and D 221 87 Lund Sweden

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Abstract  

Investigation into the thermal behavior of orthorhombic Forms I and II of spironolactone, by means of differential scanning calorimetry and high-resolution X-ray powder diffraction, showed that Form I melts then recrystallizes into Form II at 373–393 K, i.e. in the temperature range within which high resolution X-ray powder diffration showed that Form I transforms into Form II. Refinements of the lattice parameters of the two forms indicated that Form I is denser than Form II in the range from 298 K up to the temperature at which it melts.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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