Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 90: Issue 2
Study of the quaternary system(+) and (−)5-phenyl-5-trifluoromethyl-imidazolidine-2,4-dione/(−)1-phenylethylamine/ethanol at 20°C under atmospheric pressure
Authors:
F. Querniard SMS, UPRES EA3233-IRCOF, Université de Rouen Unité de Croissance Cristalline et de Modélisation Moléculaire 76821 Mont Saint Aignan Cedex France

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Julie Linol SMS, UPRES EA3233-IRCOF, Université de Rouen Unité de Croissance Cristalline et de Modélisation Moléculaire 76821 Mont Saint Aignan Cedex France

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Y. Cartigny SMS, UPRES EA3233-IRCOF, Université de Rouen Unité de Croissance Cristalline et de Modélisation Moléculaire 76821 Mont Saint Aignan Cedex France

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G. Coquerel SMS, UPRES EA3233-IRCOF, Université de Rouen Unité de Croissance Cristalline et de Modélisation Moléculaire 76821 Mont Saint Aignan Cedex France

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Pages:
359–365
Online Publication Date:
07 Dec 2007
Publication Date:
01 Nov 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-8394-z
Keywords:
double salt; hydantoins; pasteurian resolution; phase equilibria
Restricted access

Abstract  

The resolution of (�)-5-phenyl-5-trifluoromethyl-imidazolidine-2,4-dione ((�)-CF361H hereafter) using 1-phenyl-ethylamine (αMBA hereafter) in ethanol was investigated. At 20�C, the evolution of the resolution efficiency vs. the excess of αMBA was studied by establishing a part of the quaternary system: (+) and (−)-CF361H/(−)-αMBA/ethanol. Competition between two equilibria has been highlighted: •  Metastable equilibria between distereomeric salts ((�)-CF361H and enantiopure (−)-αMBA). •  Stable equilibria involving a double salt Q which exhibits a non-congruent solubility. The presence of this double salt leads to the resolution of diastereomeric salts but can drastically drop the yield if nothing could act as inhibitor of its nucleation and growth.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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