Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 91: Issue 1
Development of termogravimetric method for quantitative determination of ketoconazole
Authors:
Ana Gomes Cidade Universitária-Campus I-CCS-João Pessoa Federal University of Paraíba-UFPB, Unified Laboratory Development and Medicine Assays-LUDEM Paraíba Brasil

Search for other papers by Ana Gomes in
Current site
Google Scholar
PubMed Close
,
Lidiane Correia Cidade Universitária-Campus I-CCS-João Pessoa Federal University of Paraíba-UFPB, Unified Laboratory Development and Medicine Assays-LUDEM Paraíba Brasil

Search for other papers by Lidiane Correia in
Current site
Google Scholar
PubMed Close
,
Mônica da Silva Simões Cidade Universitária-Campus I-CCS-João Pessoa Federal University of Paraíba-UFPB, Unified Laboratory Development and Medicine Assays-LUDEM Paraíba Brasil

Search for other papers by Mônica da Silva Simões in
Current site
Google Scholar
PubMed Close
, and
R. Macêdo Cidade Universitária-Campus I-CCS-João Pessoa Federal University of Paraíba-UFPB, Unified Laboratory Development and Medicine Assays-LUDEM Paraíba Brasil

Search for other papers by R. Macêdo in
Current site
Google Scholar
PubMed Close
Pages:
317–321
Online Publication Date:
26 Sep 2007
Publication Date:
01 Jan 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-8165-x
Keywords:
Antoine equation; ketoconazole; Langmuir equation; thermogravimetry; vapor pressure
Restricted access

Abstract  

The objective of this work was to develop and validate a fast and reproducible method which is able to determine the concentration of ketoconazole in raw materials and tablets. The samples were analyzed by dynamic thermogravimetry at heating rates of 10, 20, 40, 60 and 80°C min−1 in nitrogen and nitrogen-synthetic air mixture. The concentrations of ketoconazole in the raw material and in the tablets were obtained from the vapor pressure curves. The data showed that there is no significant difference between the vapor pressure profiles of ketoconazole itself and in its tablet in both studied environmental conditions confirming that the process is really vaporization. The concentration of ketoconazole was determined in the raw material and tablets of the drug.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2024 14 0 0
May 2024 3 0 0
Jun 2024 6 0 0
Jul 2024 0 0 0
Aug 2024 11 0 0
Sep 2024 9 0 0
Oct 2024 6 0 0