Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 93: Issue 2
Application of thermal analysis in study of binary mixtures with metformin
Authors:
Ana Santos Federal University of Pernambuco, UFPE Pharmaceutical Sciences Department Prof. Moraes Rego Avenue, 1235, University City Zip. 50670-901 Recife PE Brazil

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I. Basílio Federal University of Paraiba, UFPB Unified Laboratory of Medicine Development and Assay, LUDEM Campus I Zip. 58059-900 João Pessoa PB Brazil

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F. de Souza Federal University of Paraiba, UFPB Unified Laboratory of Medicine Development and Assay, LUDEM Campus I Zip. 58059-900 João Pessoa PB Brazil

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A. Medeiros Federal University of Pernambuco, UFPE Pharmaceutical Sciences Department Prof. Moraes Rego Avenue, 1235, University City Zip. 50670-901 Recife PE Brazil

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Márcia Pinto Federal University of Pernambuco, UFPE Pharmaceutical Sciences Department Prof. Moraes Rego Avenue, 1235, University City Zip. 50670-901 Recife PE Brazil

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D. de Santana Federal University of Pernambuco, UFPE Pharmaceutical Sciences Department Prof. Moraes Rego Avenue, 1235, University City Zip. 50670-901 Recife PE Brazil

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R. Macêdo Federal University of Paraiba, UFPB Unified Laboratory of Medicine Development and Assay, LUDEM Campus I Zip. 58059-900 João Pessoa PB Brazil

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Pages:
361–364
Online Publication Date:
22 Jul 2008
Publication Date:
01 Aug 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-7876-3
Keywords:
compatibility; metformin; thermal analysis
Restricted access

Abstract  

Thermal analysis is an essential analytical tool in development of new formulations as well as to study the interaction between drugs and excipients. This work aims to investigate the possible interactions between metformin and excipients as microcrystalline cellulose (Microcel MC101®), starch sodium glycolate (Explosol®), sodium croscarmellose (Explosel®), PVP K30, magnesium stearate, starch and lactose, usually employed in pharmaceutical products. TG, DSC and DTA techniques were used for the thermal characterization to track if the thermal properties of the drug substance were modified in the mixture. Disregard of the starch and lactose systems, no changes in thermal behavior of mixtures were found. Thermogravimetric studies (TG) of metformin and its binary mixtures showed different thermal behavior.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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