Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 93: Issue 2
Microcalorimetric studies on the antimicrobial actions of different cephalosporins
Authors:
L. Yang

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F. Xu Chinese Academy of Sciences Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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L. Sun Chinese Academy of Sciences Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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Z. Zhao Chinese Academy of Sciences Division of Biotechnology, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 P.R. China

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C. Song Dalian Institute of Drug Detection Dalian 116021 P.R. China

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Pages:
417–421
Online Publication Date:
27 Jan 2008
Publication Date:
01 Aug 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-8680-9
Keywords:
cefazolin sodium; cefonicid sodium; cephalosporins; E. coli DH5α; inhibition; microcalorimetry
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Abstract  

Microcalorimetry was applied to study the effect of cephalosporins (cefazolin sodium and cefonicid sodium) on the E. coli growth. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37°C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time corresponding to the maximum power output (tm) were calculated. The change tendencies of k, with the increasing of concentration (C) of the two cephalosporins, are similar which show that cefazolin sodium and cefonicid sodium have the same inhibitory mechanism. The experimental results reveal that cefonicid sodium has a stronger antibacterial activity towards E. coli than that of cefazolin sodium and this was coincide with the clinical manifestations.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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