Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 93: Issue 2
Is there a relationship between protein thermal stability and the denaturation heat capacity change?
Author:
G. Graziano Università del Sannio Dipartimento di Scienze Biologiche ed Ambientali Via Port’Arsa 11 82100 Benevento Italy

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Pages:
429–438
Online Publication Date:
22 Jul 2008
Publication Date:
01 Aug 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-8698-z
Keywords:
denaturation heat capacity change; enthalpy-entropy compensation; hydrophobic effect; thermal stability; work of cavity creation
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Abstract  

It is shown the non-occurrence of a correlation between the values of the denaturation temperature and those of the denaturation heat capacity change for a set of 13 proteins possessing the ‘SH3-type’ fold from both mesophilic and thermophilic microorganisms. This seems to be a rather general result, because, fixed the size and the folding pattern, the denaturation heat capacity change is a nearly constant quantity, within the uncertainty limits of experimental determinations, regardless of the thermal stability of the protein. A precise definition of the thermodynamics of the hydrophobic effect is presented to clarify that the above finding does not imply that the hydrophobic effect does not play a role in the extra-thermal stability of thermophilic and hyperthermophilic proteins.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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