Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 94: Issue 1
A DSC and Raman spectroscopic study of microspheres preparedwith polar cosolvents by different techniques
Authors:
P. Sipos University of Szeged Department of Pharmaceutical Technology 6720 Szeged Hungary

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A. Szabó Budapest University of Technology and Economics Department of Organic Chemistry and Technology 1111 Budapest Hungary

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I. Erős University of Szeged Department of Pharmaceutical Technology 6720 Szeged Hungary

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Piroska Szabó-Révész University of Szeged Department of Pharmaceutical Technology 6720 Szeged Hungary

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Pages:
109–118
Online Publication Date:
15 Aug 2008
Publication Date:
01 Oct 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-007-8881-2
Keywords:
cosolvents; DSC; energy-dispersive X-ray fluorescence analysis; microsphere; Raman spectroscopy; spray drying; W/O/W multiple emulsion
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Abstract  

A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations of four polar cosolvents as independent variables. DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer. Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the microspheres.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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