Authors:
G. Bognár Veszprém County Hospital Department of Traumatology and Orthopaedics Veszprém 8200 Kórház str. 1 Hungary

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Cs. Pintér Veszprém County Hospital Department of Traumatology and Orthopaedics Veszprém 8200 Kórház str. 1 Hungary

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B. Horváth Veszprém County Hospital Department of Traumatology and Orthopaedics Veszprém 8200 Kórház str. 1 Hungary

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T. Sydo Veszprém County Hospital Department of Internal Medicine Veszprém 8200 Kórház str. 1. Hungary

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E. Ligeti Veszprém County Hospital Department of Pathology Veszprém 8200 Kórház str. 1. Hungary

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J. Pulai Veszprém County Hospital Department of Rheumatology Veszprém 8200 Kórház str. 1. Hungary

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D. Lőrinczy University of Pécs, Faculty of Medicine Institute of Biophysics 7624 Pécs Szigeti str. 12 Hungary

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Abstract  

Osteonecrosis (ON) of the femoral frequently occurs after steroid medication. One of the final pathways leading to steroid induced ON is thought to be pathologic fat metabolism. The pathobiological mechanism underlying the induction of fat metabolism outslides by steroids leading to ON has not been fully elucidated. The purpose of this study was to examine the intraoperative obtained gluteal fat tissue from ON patients with histology, gas chromatography (GC) and differential scanning calorimetry (DSC) and to compare them with otherwise healthy patient’s samples. The histological sections showed no significant differences compared with the control group. GC revealed that fraction of saturated fatty acids decreased in ON samples from mean values of controls of 24% to 21, the polyunsaturated fraction from 20 to 14%. The monounsaturated acids showed an increase from mean rate of 52% of the controls to 65% of steroid treated samples. DSC curves correlate with chromatographic analysis of the tissue fatty acids (Steroid treated, heating between 0–100°C: Tm=5.7°C, ΔH= −15.8J/g−1; heating between −20–100°C: Tm= −9.96 and 5.85°C, ΔH= −59.17 and −16.2 J g−1. Non-necrotic, heating between 0–100°C: two separable transition with Tm=5.7 and 9.9°C, total ΔH= −20.8 J g−1; heating between −20–100°C: Tm= −10.9 and 4.95°C, total ΔH= −75.8 J g−1.) Our preliminary findings are rather tendentious. Further investigations are needed with higher sample rate and under other anamnestic circumstances too.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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