During recent years, knowledge of rheumatoid arthritis has increased, and management of the disease has improved. A limited
number of papers have been published before on the subject of thermal analysis of degenerative cartilage but rheumatoid arthritis
(RA) has not been studied previously. A new protocol had to be established before the investigation. The purpose of this study
was to further characterize the altered metabolism in human RA cartilage that promotes disease progression.
Previously, these methods have not been used for this purpose. The use of thermal analysis could be an effective method for
controlling the relationship between biomarkers and disease progression.