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  • 1 Universidade Federal de Goiás – UFG LAMES – Laboratório de Métodos de Extração e Separação, Instituto de Química Campus Samambaia CEP 74001-970 Goiânia GO Brazil
  • | 2 Universidade Federal de Goiás – UFG Faculdade de Farmácia Av. Universitária com 1ª Avenida, S/N CEP 74605-220 Goiânia GO Brazil
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Abstract  

A new formulation of nifedipine tablets was prepared. The tablets were conditioned in amber-colored glass containers and placed in a climatized room at 40 °C and relative humidity of 75% for 180 days. Differential scanning calorimetry (DSC) and Thermogravimetry (TG) were used in order to evaluate the thermal properties of nifedipine, the excipients and two well-known nifedipine degradation products. There is no evidence of interaction between nifedipine and excipients or degradation products. High performance liquid chromatography (HPLC) was used in the dosage of nifedipine tablets before and after acclimatized exposure. Results show that DSC and TG offer important data for a more detailed assessment of the stability of a pharmaceutical formulation.

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