Authors:
María Moyano Universidad de Buenos Aires Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica Junín 956 1113 Buenos Aires Argentina

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Adriana Broussalis Universidad de Buenos Aires Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica Junín 956 1113 Buenos Aires Argentina

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Adriana Segall Universidad de Buenos Aires Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica Junín 956 1113 Buenos Aires Argentina

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Abstract

Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of lipoic acid with some currently employed cosmetic excipients. In the first phase of the study DSC was used as a tool to detect any interaction. Based on the DSC results alone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butylated hydroxytoluene, non ionic self emulsifying wax, propylene glycol and acetylated lanolin were found to exhibit interaction with lipoic acid. Stressed binary mixtures (stored at 50 °C for 1 week) of lipoic acid and excipients were evaluated by HPLC. Binary mixtures were evaluated by IR spectroscopy.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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