Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 99: Issue 2
Predicting eutectic behavior of drugs and excipients by unique calculations
Authors:
Satya Girish Avula 2801 W. Bancroft Street, Mail Stop No. 331, Toledo, OH, 43606-3390, USA

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Kenneth Alexander 2801 W. Bancroft Street, Mail Stop No. 331, Toledo, OH, 43606-3390, USA

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Alan Riga 2801 W. Bancroft Street, Mail Stop No. 331, Toledo, OH, 43606-3390, USA

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Pages:
655–658
Online Publication Date:
05 Jan 2010
Publication Date:
01 Feb 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-009-0595-1
Keywords:
Eutectics; Phase diagrams; Differential Scanning Calorimetry; Solubility
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Abstract

A eutectic is formed from a mixture of two or more solids and has a melting point lower than that of each of its constituents. It is generally represented by a phase diagram where the liquid and solid phases impact upon each other with a value known as the eutectic point. In pharmaceuticals, poor water solubility is a major obstacle for releasing new dosage forms into the market. Eutectic formation overcomes these problems. Preparation of a phase diagram by Differential Scanning Calorimetry can determine eutectic properties, but it is tedious. A modified Van't Hoff (VH) equation was used in this study. Devalina Law developed a dimensionless index for the VH equation. The difference in melting points of an excipient polymer and drug are divided by the slope of the VH equation. In previous studies, five excipient–drug compositions were evaluated. The final index relationship was in good agreement except for the salt, quinine sulfate. In order to test the validity of the VH index, further studies of PEG with acetylsalicylic acid, acetaminophen, diflunisal, dimenhydrinate, ketoconazole, and mefenamic acid were performed.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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