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  • 1 Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland
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Abstract

Papaverine hydrochloride decomposes in solution easily to papaverinol, papaveraldine and 2,3,9,10-tetramethoxy-12-oxo-12-H-indolo[2,1-a]isoquinolinium chloride 1. The structure of the last compound has been elucidated lately. On the addition of alkali, the brown solution of 1 bleaches. A new compound i.e. 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 2 is formed. This paper reports the optimization of the compound 2 preparation.

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