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  • 1 Budapest University of Technology and Economics Department of Organic Chemistry and Technology Budafoki út 8 1111 Budapest Hungary
  • 2 Budapest University of Technology and Economics Department of Inorganic and Analytical Chemistry Szt. Gellért tér 4 1111 Budapest Hungary
  • 3 Budapest University of Technology and Economics Research Group for Organic Chemical Technology, Hungarian Academy of Sciences, Department of Organic Chemistry and Technology Budafoki út 8 1111 Budapest Hungary
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Abstract  

Various (±)-trans-2-arylnitrocyclohexane derivatives were hydrogenated to the corresponding amines over a Pd/C catalyst in methanol at 25–60 °C and 1–12 bar. These (±)-trans-2-arylcyclohexylamines are important and valuable key intermediates for the stereoselective synthesis of phenantridine-based Amaryllidaceae alkaloid analogues having cytostatic activity.