300,000 reports inNature during the 1869–1998 period have been reviewed. The distribution of articles by subfields was determined. Additional sources of information were several journals on analytical chemistry and papers at the Pittsburg conference series during 1950–1999. The methodology used is based on the analysis of the average age of employed instruments. The agreement between scientometric data from various sources of information depends on the development stage of the field of science. Calculated and measured scientometric curves were compared. One of the key trends in the development of basic sciences, namely, the increase of articles dealing with instrumental analytical chemistry, inNature is revealed.