Patent citations to the research literature offer a way for identifying and comparing contributions of scientific and technical knowledge to technological development. This case study applies this approach through a series of analyses of citations to Dutch research papers listed on Dutch-invented and foreign patents granted in the US during the years 1987–1996.First, we examined the general validity and utility of these data as input for quantitative analyses of science-technology interactions. The findings provide new empirical evidence in support of the general view that these citations reflect genuine links between science and technology. The results of the various analyses reveal several important features of industrially relevant Dutch science: (1) the international scientific impact of research papers that are also highly cited by patents, (2) the marked rise in citations to Dutch papers on foreign-invented patents; (3) the large share of author-inventor self-citations in Dutch-invented patents; (4) the growing relevance of the life sciences, (5) an increase in the importance of scientific co-operation. We also find significant differences between industrial sectors as well as major contributions of large science-based multinational enterprises, such as Philips, in domestic science-technology linkages.The paper concludes by discussing general benefits and limitations of this bibliometric approach for macro-level analysis of science bases in advanced industrialised countries like the Netherlands.