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  • 1 Institute for Advanced Social Studies, Spanish National Research Council (IESA-CSIC) Campo Santo de los Mártires, 7 14004 Córdoba Spain
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Studies of university–industry collaboration remain subject to important limitations due to the shortage of empirical data and a lack of consistency in that obtained to date. This article puts into practice a set of universities Third Mission indicators in a regional innovation system. Selected indicators previously compiled from literature were reorganized and pre-tested. We have undertaken two face-to-face surveys of 737 firms and 765 heads of research teams, respectively. The results test the validation of indicators and provide a complex map of university–industry linkages as well as some observations on the flexibility needed to address this issue.