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Seth J. Gillihan
Seth J. Gillihan
Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, USA
Center for the Treatment and Study of Anxiety, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, 6th Floor, Philadelphia, PA, 19104, USA
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Center for the Treatment and Study of Anxiety, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, 6th Floor, Philadelphia, PA, 19104, USA
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Geena Mary V. Sankoorikal
Geena Mary V. Sankoorikal
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
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Edward S. Brodkin
Edward S. Brodkin
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
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Martha J. Farah
Martha J. Farah
Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, USA
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Abstract
Despite the significant associations between the short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) and various psychiatric disorders, the S allele has persisted at relatively high prevalence in the human population worldwide. Based on findings of greater amygdala activity among S allele carriers both at rest and in response to threat-relevant stimuli, the S allele appears to be associated with greater vigilance for danger; therefore we hypothesized that the S allele would be associated with lower scores on risk-related traits. In order to test this hypothesis we assessed the 5-HTTLPR genotype of 81 individuals of European ancestry and tested for an effect of genotype on two dimensions of risk-related behavior: venturesomeness and impulsivity. Results revealed significantly lower venturesomeness and a trend toward lower impulsivity associated with the S allele. We speculate that relatively greater vigilance for and avoidance of danger may counteract the disease risk associated with the 5-HTTLPR S allele and contribute to its persistence at high prevalence in the human population. Replication in a larger sample is necessary in order to confirm these associations.
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-
F. L. Askénazy K. Sorci M. Benoit K. Lestideau M. Myquel Y. Lecrubier 2003 Anxiety and impulsivity levels identify relevant subtypes in adolescents with at-risk behavior Journal of Affective Disorders 74 219 227.
-
A. T. Beck R. A. Steer G. K. Brown 1996 Beck Depression Inventory Manual 2 Psychological Corporation San Antonio, TX.
-
I. Beck D. J. M. Smits L. Claes W. Vandereycken P. Bijttebier 2009 Psychometric evaluation of the Behavioral Inhibition/Behavioral Activation System Scales and the Sensitivity to Punishment and Sensitivity to Reward Questionnaire in a sample of eating disordered patients Personality and Individual Differences 47 407 412.
-
T. Canli M. Qui K. Omura E. Congdon B. W. Haas Z. Amin et al.2006 Neural correlates of epigenesis Proceedings of the National Academy of Sciences 103 16033 16038.
-
A. Caspi K. Sugden T. E. Moffitt A. Taylor I. W. Craig H. Harrington et al.2003 Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene Science 301 386 389.
-
H. Cohen D. Buskila L. Neumann R. P. Ebstein 2002 Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits Arthritis and Rheumatism 46 845 847.
-
P. T. Costa Jr. R. R. Mccrae 1997 Stability and change in personality assessment: The revised NEO Personality Inventory in the year 2000 Journal of Personality Assessment 68 86 94.
-
S. B. G. Eysenck H. J. Eysenck 1978 Impulsiveness and venturesomeness: Their position in a dimensional system of personality description Psychological Reports 43 1247 1255.
-
J. Gelernter J. F. Cubells J. R. Kidd A. J. Pakstis K. K. Kidd 1999 Population studies of polymorphisms of the serotonin transporter protein gene American Journal of Medical Genetics (Neuropsychiatric Genetics) 88 61 66.
-
J. Gelernter H. Kranzler E. F. Coccaro L. J. Siever A. S. New 1998 Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects American Journal of Psychiatry 155 1332 1338.
-
S. J. Gillihan M. J. Farah G. M. V. Sankoorikal J. Breland E. S. Brodkin 2007 Association between serotonin transporter genotype and extraversion Psychiatric Genetics 17 351 354.
-
T. E. Goldberg R. Kotov A. T. Lee P. K. Gregersen T. Lencz et al.2009 The serotonin transporter gene and disease modification in psychosis: Evidence for systematic differences in allelic directionality at the 5-HTTLPR locus Schizophrenia Research 111 103 108.
-
B. D. Greenberg Q. Li F. R. Lucas S. Hu L. A. Sirota J. Benjamin et al.2000 Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample American Journal of Medical Genetics (Neuropsychiatric Genetics) 96 202 216.
-
A. R. Hariri E. M. Drabant K. E. Munoz B. S. Kolachana V. S. Mattay M. F. Egan et al.2005 A susceptibility gene for affective disorders and the response of the human amygdala Archives of General Psychiatry 62 146 152.
-
T. Hensch H.-L. Wargelius U. Herold A. Strobel L. Oreland B. Brocke 2008 Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2β coding gene Neuroscience Letters 436 67 71.
-
X.-Z. Hu R. H. Lipsky G. Zhu L. A. Akhtar J. Taubman B. D. Greenberg et al.2006 Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder American Journal of Human Genetics 78 815 826.
-
X. Hu G. Oroszi J. Chun T. L. Smith D. Goldman M. A. Schuckit 2005 An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk Alcoholism: Clinical and Experimental Research 29 8 16.
-
K. S. Kendler J. W. Kuhn J. Vittum C. A. Prescott B. Riley 2005 The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication Archives of General Psychiatry 62 529 535.
-
C. M. Kuhnen J. Y. Chiao 2009 Genetic determinants of financial risk taking PLoS ONE 4 e4362.
-
K.-P. Lesch D. Bengel A. Heils S. Z. Sabol B. D. Greenberg S. Petri et al.1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527 1531.
-
D. Li L. He 2006 Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior Molecular Psychiatry 12 47 54.
-
P.-Y. Lin 2006 Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder Progress in Neuropsychopharmacology and Biological Psychiatry 31 683 689.
-
F. E. Lotrich B. G. Pollock 2004 Meta-analysis of serotonin transporter polymorphisms and affective disorders Psychiatric Genetics 14 121 129.
-
F. E. Lotrich B. G. Pollock R. E. Ferrell 2003 Serotonin transporter promoter polymorphism in African Americans: Allele frequencies and implications for treatment American Journal of Pharmacogenomics 3 145 147.
-
F. G. Moeller D. M. Dougherty E. S. Barratt J. M. Schmitz A. C. Swann J. Grabowski 2001 The impact of impulsivity on cocaine use and retention in treatment Journal of Substance Abuse Treatment 21 193 198.
-
S. M. Moore D. A. Rosenthal 1993 Venturesomeness, impulsiveness, and risky behaviour among older adolescents Perceptual and Motor Skills 76 98.
-
M. R. Munafò S. M. Brown A. R. Hariri 2008 Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis Biological Psychiatry 63 852 857.
-
M. R. Munafò T. Clark J. Flint 2005 Promise and pitfalls in the meta-analysis of genetic association studies: A response to Sen and Schinka Molecular Psychiatry 10 895 897.
-
M. R. Munafò J. Flint 2004 Meta-analysis of genetic association studies Trends in Genetics 20 439 444.
-
M. R. Munafò N. B. Freimer W. Ng R. Ophoff J. Veijola J. Miettunen et al.2009 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data American Journal of Medical Genetics (Neuropsychiatric Genetics) 150B 271 281.
-
O. Pucilowski A. Plaznik W. Kostowski 1985 Aggressive behavior inhibition by serotonin and quipazine injected into the amygdala in the rat Behavioral and Neural Biology 43 58 68.
-
S. Ramboz R. Oosting D. A. Amara H. F. Kung P. Blier et al.1998 Serotonin receptor 1A knockout: An animal model of anxiety-related disorder Neurobiology 95 14476 14481.
-
H. Rao S. J. Gillihan J. Wang M. Korczykowski G. M. V. Sankoorikal K. A. Kaercher et al.2007 Genetic variation in serotonin transporter alters resting brain function in healthy individuals Biological Psychiatry 62 600 606.
-
S. J. Semple J. Zians I. Grant T. L. Patterson 2006 Methamphetamine use, impulsivity, and sexual risk behavior among HIV-positive men who have sex with men Journal of Addictive Diseases 25 105 114.
-
S. Sen M. Burmeister D. Ghosh 2005 5-HTTLPR and anxiety-related personality traits meta-analysis revisited: Response to Munafo and colleagues Molecular Psychiatry 10 893 895.
-
T. V. Shcherbatykh V. E. Golimbet V. A. Orlova V. G. Kaleda I.V. Oleichik L. M. Abramova et al.2000 Polymorphisms in the human serotonin transporter gene in endogenous psychoses Russian Journal of Genetics 36 1445 1448.
-
M. B. Stein N. J. Schork J. Gelernter 2008 Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders Neuropsychopharmacology 33 312 319.
-
P. J. Whalen 1998 Fear, vigilance, and ambiguity: Initial neuroimaging studies of the human amygdala Current Directions in Psychological Science 7 177 188.
-
J. M. Zelenski R. J. Larsen 1999 Susceptibility to affect: A comparison of three personality taxonomies Journal of Personality 67 761 791.
| Journal of Evolutionary Psychology | |
|---|---|
| Language | English |
| Size | |
| Year of Foundation |
2007 (2003) |
| Publication Programme |
changed title |
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| Founder | Akadémiai Kiadó |
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| Publisher | Akadémiai Kiadó |
| Publisher's Address |
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| ISSN | 1789-2082 (Print) |
| ISSN | 2060-5587 (Online) |
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A Darwinian approach to meaning
A review of The Origins of Meaning: Language in the Light of Evolution by James R. Hurford. Oxford University Press (2007), 352 pages, Price: £21.00 ($37.32), ISBN: 0199207855 (hardback).
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