Authors:
József Tímár Országos Onkológiai Intézet, Budapest
II. sz. Patológiai Intézet, Semmelweis Egyetem, 1091 Budapest, Üllői út 93.

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Miklós Kásler Országos Onkológiai Intézet, Budapest

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Alexandra Heringh AstraZeneca Kft, Törökbálint

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Miklós Soós AuroScience Kft, Budapest

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Dóra Mathiász GlaxoSmithKline Kft, Budapest

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Anna Romány Janssen-Cilag Kft, Törökbálint

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Adrienn Józsa Roche (Magyarország) Kft, Budaörs

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László Szilák Szilák Labor Kft, Szeged

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Tamás Forrai Zenon Bio Kft, Szeged

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László Patthy MTA Enzimológiai Intézete, Budapest

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Gábor Kovács Országos Korányi TBC és Pulmonológiai Intézet, Budapest

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A fejlesztés 3. évében 8 új molekuláris diagnosztikai szolgáltatást fejlesztett ki a Konzorcium az emlőrák, vastagbélrák, tüdőrák, GIST és melanoma prognosztikája és predikciója számára. A kutatási periódusban 2 szabadalmat jelentett be új típusú mitogén/motogén jelpálya-módosításra. Emberi daganatok preklinikai modelljein az eritropoetin erekre gyakorolt hatásainak funkcionális képalkotó vizsgálatokkal történő mérését dolgozta ki. Humán melanoma modelleken a szisztémás progresszió genomikai jellemzőit határozta meg.

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  • 2 Linger, R, Dudakia, D, Oláh, E et al. 2008 Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors Genes Chromosomes Cancer 47 247252.

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  • 3 Nagahashi, M, Ajioka, Y, Lang, I, Szentirmay, Z et al. 2008 Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary World J Gastroenterol 14 7075.

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  • 4 Illés, A, Simon, Z, Tóth, E et al. 2008 Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) – Clinicopathological features based on the data of two Hungarian lymphoma centres Pathol Oncol Res 14 411421.

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  • 5 Szőke, J, Csernák, E, Szentirmay, Z 2008 Mutational analysis of the epidermal growth factor receptor gene in clinical samples of adenocarcinoma of the lung Revis Med Farmac 54 Suppl 3 495498.

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  • 6 Kovács, ME, Papp, J, Szentirmay, Z et al. 2009 Deletions removing the last exon of TACSTD’ constitute a distinct class of mutations predisposing to Lynch syndrome Hum Mutat 30 197203.

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  • 7 Dome, B, Dobos, J, Tovari, J et al. 2008 Circulating bone marrow-derived endothelial progenitor cells: characterization, mobilization and therapeutic considerations in malignant disease Cytometry A 73 186193.

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  • 8 Lövey, J, Bereczky, B, Gilly, R et al. 2008 Recombinant human erythropoietin-alpha improves the efficacy of radiotherapy of a human tumor xenograft, affecting tumor cells and microvessels Strahlenther Oncol 184 17.

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  • 10 Dome, B, Timar, J, Ladanyi, A et al. 2009 Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: from biology to therapy Crit Rev Oncol Hematol 69 108124.

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  • 11 Bogos, K, Renyi-Vamos, F, Dobos, J et al. 2009 High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer Clin Cancer Res 15 17411746.

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  • 12 Tímár, J, Döme, B 2008 Antiangiogenic drugs and tyrosine kinases Anticancer Agents Med Chem 5 462469.

  • 13 Tóvári, J, Pirker, R, Tímár, J et al. 2008 Erythropoietin in cancer: an update Curr Mol Med 8 481491.

  • 14 Dome, P, Teleki, Z, Rihmer, Z et al. 2009 Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul Mol Psychiatry 14 523531.

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  • 15 Tímár, J, Győrffy, B, Rásó, E. Gene signature of the metastatic potential of cutaneous melanoma. Clin Exp Metast 2009 (in press).

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  • 16 Réti, A, Barna, G, Pap, E et al. 2008 Enhancement of 5-fluorouracyl efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells Pathol Oncol Res 1007/s12253-008-9126-9.

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  • 17 Kralovánszky, J 2008 Törekvések a daganatkemoterápia hatékonyságának fokozására Magyar Onkológia 52 918.

  • 18 Komlósi, V, Budai, B, Adleff, V, et al. Serine hydroxymethyltransferase (SHMT) C1420T and methylenetetrahydrofolate reductase C677T polymorphisms in colorectal cancer and their influence on the serum homocysteine level. Eur J Hum Genet, Manuscript number: 740-08-EWJHG (Submitted 2008).

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  • 19 Bácsi, K, Hitre, E, Kósa, JP et al. 2008 Effects of the lactase 13910C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population BMC Cancer 8 317.

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Magyar Onkológia
Language Hungarian
Size  
Year of
Foundation
1956
Publication
Programme
 
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Onkológusok Társasága
Founder's
Address
H-1122 Budapest, Hungary Ráth György u. 7-9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0025-0244 (Print)
ISSN 2060-0399 (Online)

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