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  • 1 Megyei Onkológiai Központ, Békés Megyei Képviselőtestület Pándy Kálmán Kórháza, 5700 Gyula, Semmelweis u. 1.
  • | 2 Infektológiai (Hepatológia és Immunológia) Osztály, Békés Megyei Képviselőtestület Pándy Kálmán Kórháza Gyula, Gyula
  • | 3 I. sz. Belgyógyászati Osztály, Békés Megyei Képviselőtestület Pándy Kálmán Kórháza Gyula, Gyula
  • | 4 Innere Abteilung, Kreiskrankenhaus Sigmaringen, Sigmaringen, Németország
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Napjaink modern életformájának terjedése nemcsak az elhízás, a 2-es típusú diabétesz és a kardiovaszkuláris kórképek kialakulásának kedvez, hanem a malignus tumoros betegségek számának rohamos növekedésével is jár. Ma már egyre több, elsősorban epidemiológiai jellegű vizsgálat bizonyítja, hogy a 2-es típusú cukorbetegség és a legtöbb daganat kialakulása között összefüggés van, melynek oka a kórfolyamatok közös részleteiben keresendő. Az egyik ilyen részlet a szervezet kezdeti hyperinsulinaemiával és kései hyperglycaemiával kísért inzulinrezisztens állapotának létrejötte. Ezt daganatos betegekben a tumorszövet fokozott inzulinérzékenysége és glükózfelvétele egészíti ki. A tumoros szervezetben tehát a daganat számára előnyös, a 2-es típusú diabéteszre jellemző szénhidrát-anyagcserezavar alakul ki. Ennek megfelelően logikusnak tűnik orális inzulinszenzitizáló antidiabetikumok alkalmazási lehetőségének felvetése tumorellenes indikációban is. Az irodalmi adatok túlnyomó része alátámasztja ezt az elgondolást, mind a biguanid típusú metformin, mind a tiazolidindionok (TZD) esetében. Kedvezőek az előzetes eredmények az inzulinszerű növekedési faktor receptor (IGFR) elleni monoklonális antitest-készítmények daganatellenes alkalmazásának terén is. A cukorbetegség és a malignus tumorok komplex anyagcserekontroll részeként történő, együttes kezelése tehát újabb lehetőségeket adhat az onkológiai terápiák körében, melyek révén nemcsak a szervezetet erősítjük a tumor ellenében, hanem a daganatot is gyengítjük a szervezet védelmében. Magyar Onkológia 54: 315–323, 2010

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Magyar Onkológia
Language Hungarian
Size  
Year of
Foundation
1956
Publication
Programme
 
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Onkológusok Társasága
Founder's
Address
H-1122 Budapest, Hungary Ráth György u. 7-9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0025-0244 (Print)
ISSN 2060-0399 (Online)

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