Author:
Authors:
and
A. Zięba
A. Zięba
Department of Organic Chemistry, The Medical University of Silesia, ul. Jagiellońska 4, 41-200, Sosnowiec, Poland
Search for other papers by A. Zięba in
Current site
Google Scholar
PubMed
Search for other papers by A. Zięba in
Current site
Google Scholar
PubMed
W. Prus
W. Prus
Institute of Environmental Protection and Engineering, The University of Bielsko-Biała, ul. Willowa 2, 43-309, Bielsko-Biała, Poland
Search for other papers by W. Prus in
Current site
Google Scholar
PubMed
Search for other papers by W. Prus in
Current site
Google Scholar
PubMed
Summary
The lipophilicity RM0 and log PTLC of thirteen novel, potentially biologically active, 12H-quino[3,4-b][1,4]benzothiazinium salts have been determined by reversed-phase thin-layer chromatography using RP-18 silica plates and methanol-aqueous Tris buffer solution mixtures as mobile phases. RM values of the compounds were linearly dependent on methanol concentration; extrapolation of these to 0% methanol gave the lipophilicity RM0. log PTLC was obtained from RM0 by use of a calibration curve obtained for five standards of known experimental lipophilicity (log P). Lipophilicity log Pcalcd for the thirteen quinobenzothiazines was calculated by use of nine software products. The values determined were discussed in terms of structure-lipophilicity relationships. The results indicate that chromatographic lipophilicity RM0 can be used as a measure of the lipophilicity of the azaphenothiazine derivatives investigated.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
[1]. M.S. Tute 1996 V. Pliska B. Testa H. van de Waterbeemd Lipophilicity in Drug Action and Toxicology VCH Weinheim 7–26.
-
[2]. G.M. Meisenberg and W.H. Simmons, Principles of Medical Biochemistry, Mosby, 1998.
-
[3]. M. Sainsbury 1989 A. Katritzky C.W. Rees Comprehensive Heterocyclic Chemistry, Vol. 3 Pergamon Press Oxford 995–1038.
-
[4]. J.E.C. Reynolds 1989 The Pharmacopoeia 29 The Pharmaceutical Press London 765.
-
[5]. E.I. Isaacson 1998 J.N. Delgado W.A. Remers Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry 10 Lippincott-Raven Philadelphia 435–461.
-
[6]. G.W. Kaatz V.V. Mondgal S.M. Seo J.M. Kristiansen 2003 Antimicrob. Agents Chemother. 47 719.
-
[7]. A. Aszalós 2003 Acta Microb. Immun. Hung. 50 43.
-
[8]. N. Motohashi 1988 R.R. Gupta Phenothiazines and 1,4-Benzothiazines: Chemical and Biomedical Aspects Elsevier Amsterdam 705–774.
-
[9]. A. Zięba , A. Maślankiewicz, and K. Suwińska, Eur. J. Org. Chem., 2947 (2000).
-
[10]. A. Zięba K. Suwińska 2006 Heterocycles 68 495.
-
[11]. A. Zięba , in press 2009.
-
[12]. L. Stefaniak G.A. Webb M. Witanowski 1993 Annu. Rep. NMR Spectrosc. 25 70.
-
[13]. N. Bodor Z. Garbany C.K. Wong 1989 J. Am. Chem. Soc. 111 3783.
-
[14]. K. Dross C. Sonntag R. Mannhold 1994 J. Chromatogr. A 673 113.
-
[15]. R. Mannhold G. Cruciani K. Dross R. Rekker 1998 J. Comput. Aided Mol. Design 12 573.
-
[17]. S. Gocan G. Cimpan J. Comer 2005 E. Grushka N. Grinberg Advances in Chromatography, Vol. 44 Taylor and Francis Boca Raton, London, New York 79–176.
-
[18]. A. Leo 1993 Chem. Rev. 93 1281.
-
[19]. The Cambridge Structural Database, The Cambridge Crystallographic Data Centre, Cambridge, 2005.
-
[20]. S.S.C. Chu 1988 R.R. Gupta Phenothiazines and 1,4-Benzothiazines: Chemical and Biomedical Aspects Elsevier Amsterdam 475–526.
Senior editors
Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland
Editors(s)
- Danica Agbaba, University of Belgrade, Belgrade, Serbia (1953-2024)
- Łukasz Komsta, Medical University of Lublin, Lublin, Poland
- Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
- Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland
Editorial Board
- Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
- Jacek Bojarski, Jagiellonian University, Kraków, Poland
- Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
- Michał Daszykowski, University of Silesia, Katowice, Poland
- Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
- Attila Felinger, University of Pécs, Pécs, Hungary
- Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
- Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
- Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
- Urszula Hubicka, Jagiellonian University, Kraków, Poland
- Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
- Huba Kalász, Semmelweis University, Budapest, Hungary
- Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
- Imre Klebovich, Semmelweis University, Budapest, Hungary
- Angelika Koch, Private Pharmacy, Hamburg, Germany
- Piotr Kus, Univerity of Silesia, Katowice, Poland
- Debby Mangelings, Free University of Brussels, Brussels, Belgium
- Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
- Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
- Gertrud Morlock, Giessen University, Giessen, Germany
- Anna Petruczynik, Medical University of Lublin, Lublin, Poland
- Robert Skibiński, Medical University of Lublin, Lublin, Poland
- Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
- Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
- Adam Voelkel, Poznań University of Technology, Poznań, Poland
- Beata Walczak, University of Silesia, Katowice, Poland
- Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
- Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation
SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl
Indexing and Abstracting Services:
- Science Citation Index
- Sci Search
- Research Alert
- Chemistry Citation Index and Current Content/Physical
- Chemical and Earth Sciences
- SCOPUS
- GoogleScholar
- Index Copernicus
- CABI
- CABELLS Journalytics
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 1.7 |
| Rank by Impact Factor | Q3 (Chemistry, Analytical) |
| Journal Citation Indicator | 0.43 |
| Scopus | |
| CiteScore | 4.0 |
| CiteScore rank | Q2 (General Chemistry) |
| SNIP | 0.706 |
| Scimago | |
| SJR index | 0.344 |
| SJR Q rank | Q3 |
| Acta Chromatographica | |
|---|---|
| Publication Model | Online only Gold Open Access |
| Submission Fee | none |
| Article Processing Charge | 400 EUR/article Effective from 1st Feb 2025: 700 EUR/article |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription Information | Gold Open Access |
| Purchase per Title | |
| Acta Chromatographica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1988 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Institute of Chemistry, University of Silesia |
| Founder's Address |
PL-40-007 Katowice, Poland, Bankowa 12 |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2083-5736 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Aug 2024 | 0 | 25 | 10 |
| Sep 2024 | 0 | 10 | 1 |
| Oct 2024 | 0 | 10 | 5 |
| Nov 2024 | 0 | 40 | 1 |
| Dec 2024 | 0 | 42 | 0 |
| Jan 2025 | 0 | 16 | 0 |
| Feb 2025 | 0 | 0 | 0 |
Authors:
, , , , , , and
Authors:
, , , , , , and
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory