The lipophilicity RM0 and log PTLC of thirteen novel, potentially biologically active, 12H-quino[3,4-b][1,4]benzothiazinium salts have been determined by reversed-phase thin-layer chromatography using RP-18 silica plates and methanol-aqueous Tris buffer solution mixtures as mobile phases. RM values of the compounds were linearly dependent on methanol concentration; extrapolation of these to 0% methanol gave the lipophilicity RM0. log PTLC was obtained from RM0 by use of a calibration curve obtained for five standards of known experimental lipophilicity (log P). Lipophilicity log Pcalcd for the thirteen quinobenzothiazines was calculated by use of nine software products. The values determined were discussed in terms of structure-lipophilicity relationships. The results indicate that chromatographic lipophilicity RM0 can be used as a measure of the lipophilicity of the azaphenothiazine derivatives investigated.
. M.S.Tute1996V.PliskaB.TestaH.van de WaterbeemdLipophilicity in Drug Action and ToxicologyVCHWeinheim7–26.
M.S.Tute1996V.PliskaB.TestaH.van de WaterbeemdLipophilicity in Drug Action and ToxicologyVCHWeinheim7–26.)| false